LARG and mDia1 Link Gα12/13 to Cell Polarity and Microtubule Dynamics
نویسندگان
چکیده
منابع مشابه
LARG and mDia1 Link G 12/13 to Cell Polarity and Microtubule Dynamics
Regulation of cell polarity is a process observed in all cells. During directed migration, cells orientate their microtubule cytoskeleton and the microtubule-organizing-center (MTOC), which involves integrins and downstream Cdc42 and glycogen synthase kinase-3 activity. However, the contribution of G protein-coupled receptor signal transduction for MTOC polarity is less well understood. Here, w...
متن کاملEb1 Proteins Regulate Microtubule Dynamics, Cell Polarity, and Chromosome Stability
The EB1 family represents a highly conserved group of proteins, present in yeast through humans, that localize to spindle and cytoplasmic microtubules, especially at their distal tips. The budding yeast homologue of EB1, Bim1p, regulates microtubule stability and is important for positioning the mitotic spindle, anchoring it to the bud through astral microtubule attachment to the cortical prote...
متن کاملMicrotubule-induced cortical cell polarity.
Most cells are polarized. Embryonic and stem cells can use their polarity to generate cell diversity by asymmetric cell division, whereas differentiated cells use their polarity to execute specific functions. For example, fibroblasts form an actin-rich leading edge required for cell migration, neurons form distinctive axonal and dendritic compartments important for directional signaling, and ep...
متن کاملConnexin43 Modulates Cell Polarity and Directional Cell Migration by Regulating Microtubule Dynamics
Knockout mice deficient in the gap junction gene connexin43 exhibit developmental anomalies associated with abnormal neural crest, primordial germ cell, and proepicardial cell migration. These migration defects are due to a loss of directional cell movement, and are associated with abnormal actin stress fiber organization and a loss of polarized cell morphology. To elucidate the mechanism by wh...
متن کاملCell polarity and microtubule organisation during mouse early embryogenesis.
We have studied the distribution and the role of microtubules in the major developmental events occurring during early development of the mouse. These events are the setting up of asymmetries within blastomeres, the process of asymmetrical cell division and the changes in cellular organisation taking place during epithelial differentiation.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2008
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e06-11-1045